Monogram Orthopedics

AcquiredRaised Since Featured

Precision robotics for perfect-fit knee replacements

AI-driven autonomous surgical robot and 3D-printed custom knee implants.

Founded January 2015Austin, TX~50 people$29.6M raisedFeatured at Series B

monogramtechnologies.com inLinkedIn Crunchbase

MedtechRoboticsSurgical Robotics3d PrintingAiKnee ReplacementOrthopedicsMedical Devices

About

Monogram Orthopedics (now Monogram Technologies) developed the mBôs system — a CT-based, semi-autonomous surgical robot paired with mPress 3D-printed press-fit knee implants — to deliver mass-personalized total knee arthroplasty. Founded by orthopedic surgeon Dr. Douglas Unis at Mount Sinai and led by CEO Benjamin Sexson, the company pioneered an approach where AI analyzes patient CT scans to plan surgery, a robot autonomously executes bone cuts with sub-millimeter precision, and 3D-printed implants are custom-manufactured to fit each patient's unique anatomy. The result: implants 270% more stable than off-the-shelf alternatives, with operating times cut roughly in half (40 vs 80 minutes). Monogram raised $29.6M through a groundbreaking path — crowdfunding from 22,000+ retail investors before IPO'ing on NASDAQ (MGRM), becoming only the second company to go from equity crowdfunding to public listing. The mBôs system received FDA 510(k) clearance in March 2025, and in July 2025 Zimmer Biomet announced a definitive agreement to acquire Monogram for $177M ($4.04/share upfront plus up to $12.37 in milestone-based CVRs). The acquisition closed October 2025.

DailyDropout Take

Monogram was a textbook DailyDropout discovery — a tiny crowdfunded startup taking on medtech giants with genuinely differentiated tech. The $177M Zimmer Biomet acquisition validated the thesis: autonomous surgical robotics paired with 3D-printed custom implants is the future of joint replacement.

Discovery signal: Novel autonomous robot + 3D-printed implant combo, crowdfunding-to-IPO path showed strong retail conviction, operating in massive $20B+ knee replacement market

What Makes Them Unique

First fully autonomous surgical robot in orthopedics, combining AI-driven surgical planning with 3D-printed patient-specific implants for mass-personalized knee replacements — delivering 270% more stability and halving operating time.

$177M

Acquisition Price

$29.6M

Total Raised

22,000+

Retail Investors

March 2025

FDA Clearance

Target Markets

Orthopedic Surgery CentersHospitalsJoint Replacement Clinics

Founders

Douglas Unis, MD

Founder & Chief Medical Officer

Board-certified attending orthopedic surgeon at Mount Sinai Health System. Chief of Quality Improvement for Mount Sinai West. Founded Monogram to bring robotics, 3D printing, and AI to orthopedic surgery.

Benjamin Sexson

CEO & President

CFA charterholder who joined Monogram in 2018. Previously Director of Business Development at Pro-Dex, an OEM manufacturer of orthopedic robotic end-effectors. Led Monogram from crowdfunding through NASDAQ IPO to $177M acquisition.